All-trans Retinoic Acid–Induced Isolated Myocarditis
نویسندگان
چکیده
منابع مشابه
All-trans-retinoic acid: measurement
A quantitative determination of physiological levels of all-trans-retinoic acid (vitamin A acid) in human serum has been developed. A double-phase extraction of 3.5 ml of serum followed by a specific and sensitive high performance liquid chromatography procedure allowed measurement of levels down to 1 ng/ml. Serum concentrations in 37 fasting volunteers ranged from 2.7 to 4.2 ng/ml and fitted a...
متن کاملAll-trans-retinoic acid and bleeding/thrombosis.
Hematology-Oncology Department Ospedali Riuniti Largo Barozzi, 1 24128 Bergamo (Italy) Tel. 39 035 269492, Fax 39 035 266659 E-Mail [email protected] All-trans-retinoic acid (ATRA) inhibits cell growth and proliferation by inducing cyto-differentiation and/or apoptosis in several cell types. These effects have become a therapeutic objective in human cancers. In addition to these functions, ...
متن کاملAll Trans Retinoic Acid (ATRA) induced myositis.
A 5-year-old girl presented with fever, skin and mucosal bleeds, and pallor. Her hemoglobin was 3.6 g/dL, total white cell count 4.5×103/μL and platelet count 13×103/μL. Peripheral smear revealed 30% blasts, confirmed as APML on bone marrow examination. Cytogenetic analysis showed the typical translocation of t(15:17) with 77% of interphase cells expressing PML:RARA gene fusion. Child was start...
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strong correlation was found between the two variables (r = 0.86; p<0.0001), as suggested by linear regression analysis. The best results were obtained when the number of CD34 cells in PB was greater than 50 μL, while the worst results were related to a level of less than 10 μL (Figure 1). Only in 5 cases, because of the particular clinical history of the patients, did we perform leukapheresis ...
متن کاملRetinol inhibits the growth of all-trans-retinoic acid-sensitive and all-trans-retinoic acid-resistant colon cancer cells through a retinoic acid receptor-independent mechanism.
Retinol (vitamin A) is thought to exert its effects through the actions of its metabolite, all-trans-retinoic acid (ATRA), on gene transcription mediated by retinoic acid receptors (RAR) and retinoic acid response elements (RARE). However, retinoic acid resistance limits the chemotherapeutic potential of ATRA. We examined the ability of retinol to inhibit the growth of ATRA-sensitive (HCT-15) a...
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ژورنال
عنوان ژورنال: JACC: Case Reports
سال: 2020
ISSN: 2666-0849
DOI: 10.1016/j.jaccas.2020.09.050